Journal
MUSCLE & NERVE
Volume 25, Issue 1, Pages 111-114Publisher
WILEY
DOI: 10.1002/mus.10018
Keywords
cyclosporine; diabetes mellitus; HCV infection; myasthenia gravis; tacrolimus
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Tacrolimus (FK-506) is a calcium-calcineurin inhibitor, successfully used in transplant recipients. We report the successful use of tacrolimus as a single immunosuppressant in a patient who had developed myasthenia gravis (MG) during interferon alpha treatment. In this case, the coexistence of hepatitis C and type 2 diabetes mellitus contraindicated the use of both steroids and azathioprine, and cyclosporine A, although effective, had induced renal failure. Tacrolimus proved to be effective in the treatment of MG, was not significantly hepatotoxic, and was less nephrotoxic than cyclosporine. (C) 2002 John Wiley & Sons, Inc.
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