Journal
DRUG DISCOVERY TODAY
Volume 7, Issue 1, Pages 47-55Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(01)02087-6
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The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.
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