Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 28, Issue 6, Pages 1079-1088Publisher
KARGER
DOI: 10.1159/000335864
Keywords
Cell Volume Regulation; Apoptotic Resistance; Osmotic stress; RVI
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Funding
- NIH, National Institute of Environmental Health Sciences
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES090079, ZICES102486, ZIAES090057] Funding Source: NIH RePORTER
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The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process. Copyright (C) 2011 S. Karger AG, Basel
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