Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 28, Issue 6, Pages 1061-1078Publisher
KARGER
DOI: 10.1159/000335843
Keywords
VRAC; TMEM16; TASK-2; RVD; Osmotic stress; Cell migration; Cell proliferation; Programmed cell death; Apoptosis
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Funding
- Danish Research Council (FNU and FSS)
- Carlsberg Foundation
- Lundbeck foundation
- Novo Nordisk Foundation
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This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines: nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death. Copyright c 2011 S. Karger AG, Basel
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