Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume -, Issue -, Pages 36-44Publisher
WILEY-LISS
DOI: 10.1002/jcb.10402
Keywords
PET; SPECT; CCD; HSV1-thymidine kinase; dopamine D2 receptor; luciferase; somatostatin receptor; sodium iodide transporter; gene therapy; adenovirus
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Funding
- NATIONAL CANCER INSTITUTE [P50CA086306, R01CA084572] Funding Source: NIH RePORTER
- NCI NIH HHS [P50 CA86306, R0-1 CA84572] Funding Source: Medline
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Non-invasive, quantitative and repetitive imaging of biological processes in living animals is rapidly changing the way in which many experiments in models of human disease and normal physiological processes are conducted. This review summarizes the newest molecular imaging approaches to analyzing reporter gene expression, with particular emphasis on pre-clinical cancer research. Alternative modes of imaging are summarized, followed by descriptions of the major reporter gene systems now used for radionuclide imaging in vivo of gene expression. Several somatic delivery paradigms for co-ordinate expression of therapeutic and imaging genes are presented, and our own emphasis on the dopamine D2 receptor and Herpes Sirnplex Virus Type I thymidine kinase reporter genes are detailed.
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