Journal
FREE RADICAL RESEARCH
Volume 36, Issue 12, Pages 1331-1336Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1071576021000038531
Keywords
oxidative stress; inflammation; diabetes; atherosclerosis; antioxidant; alpha tocopherol
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Funding
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [K24AT000596] Funding Source: NIH RePORTER
- NCCIH NIH HHS [K24 AT00596] Funding Source: Medline
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The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress and inflammation in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation (e.g. increased F 2 -isoprostanes) and increased DNA damage. Evidence for increased inflammation includes increased monocyte superoxide and pro-inflammatory cytokine release (IL-1, IL-6, and TNF-alpha), increased monocyte adhesion to endothelium and increased levels of plasma C-reactive protein, the prototypic marker of inflammation. Most importantly, alpha tocopherol therapy, especially at high doses, clearly shows a benefit with regards to LDL oxidation, isoprostanes and a decrease in inflammatory markers such as C-reactive protein, pro-inflammatory cytokines and PAI-1 levels. Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality.
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