Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 24, Issue 3-4, Pages 307-316Publisher
KARGER
DOI: 10.1159/000233255
Keywords
Human umbilical cord; Mesenchymal stromal cells; Intracerebral hemorrhage; Anti-inflammation; Angiogenesis
Categories
Funding
- Ministry Science & Technology of China [2006AA02A110]
- National Natural Science Foundation of China [30570905, 30600238]
- Tianjin Municipal Science and Technology Commission [07JCYBJC11200, 08ZCKFSF03200]
Ask authors/readers for more resources
Cell-based therapy represents a promising strategy in the treatment of neurological disorders. Human umbilical cord tissue has recently been recognized as an ideal source of mesenchymal stromal cells due to accessibility, vast abundance and safety. Here, an intracerebral hemorrhage (ICH) rat model was established by injection of bacterial collagenase VII and CM-Dil labeled human umbilical cord tissue derived mesenchymal stromal cells (UC-MSC) were intracerebrally transplanted into rat brain 24h after ICH. The results demonstrated that UC-MSC treatment significantly improved neurological function deficits and decreased injury volume of ICH rats. Leukocytes infiltration, microglial activation, ROS level and matrix metalloproteinases (MMPs) production were substantially reduced in peri-ICH area in cell-treated group as compared with PBS control at day 3 post-transplantation. In addition, UC-MSC treatment significantly increased vascular density in peri-ICH area and transplanted UC-MSC were found to be able to incorporate into cerebral vasculature in ipsilateral hemisphere at 14 days after transplantation. In summary, intracerebral administration of UC-MSC could accelerate neurological function recovery of ICH rat, the underlying mechanism may ascribe to their ability to inhibit inflammation and promote angiogenesis. Thus UC-MSC may provide a potential cell candidate for cell-based therapy in neurological disorders. Copyright (C) 2009 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available