Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 85, Issue 3, Pages 459-469Publisher
WILEY
DOI: 10.1002/jcb.10160
Keywords
T lymphocytes; T cell signaling; chromatin remodeling; trichostatin; systemic lupus erythematosus
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI042269] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI42269] Funding Source: Medline
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Trichostatin A (TSA) is a potent reversible inhibitor of histone deacetylase, and it has been reported to have variable effects on the expression of a number of genes. In this report, we show that TSA suppresses the expression of the T cell receptor zeta chain gene, whereas, it upregulates the expression if its homologous gene Fcepsilon receptor I gamma chain. These effects are associated with decreased intracytoplasmic-free calcium responses and altered tyrosine phosphorylation pattern of cytosolic proteins. Along with these effects, we report that TSA suppresses the expression of the interleukin-2 gene. The effects of TSA on human T cells are predominantly immunosuppressive and reminiscent of the signaling aberrations that have been described in patients with systemic lupus erythematosus.
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