Journal
CELLULAR MICROBIOLOGY
Volume 16, Issue 10, Pages 1473-1483Publisher
WILEY
DOI: 10.1111/cmi.12334
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Funding
- NIBIB NIH HHS [R21 EB017865] Funding Source: Medline
- NIGMS NIH HHS [R01 GM110215, R01 GM101189] Funding Source: Medline
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Cellular engulfment of particles, cells or solutes displaces large domains of plasma membrane into intracellular membranous vacuoles. This transfer of membrane is accompanied by major transitions of the phosphoinositide (PI) species that comprise the cytoplasmic face of membrane bilayers. Mapping of membrane PIs during engulfment reveals distinct patterns of protein and PI distributions associated with each stage of engulfment, which correspond with activities that regulate the actin cytoskeleton, membrane movements and vesicle secretion. Experimental manipulation of PI chemistry during engulfment indicates that PIs integrate organelle identity and orient signal transduction cascades within confined subdomains of membrane. These pathways are exploited by microbial pathogens to direct or redirect the engulfment process.
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