Journal
PLANTA MEDICA
Volume 68, Issue 1, Pages 45-48Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-20055
Keywords
Microsphaeropsis sp.; lichenicolous fungi; preussomerins; antiplasmodial activity; antimycobacterial activity
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A new preussomerin isomer, 3'-O-demethylpreussomerin 1, five known preussomerins E-I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C-11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.
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