Journal
CELLULAR MICROBIOLOGY
Volume 15, Issue 5, Pages 701-708Publisher
WILEY
DOI: 10.1111/cmi.12091
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Funding
- German Federal Ministry of Education and Research (BMBF: ERA Net PathoGenoMics Can- diCol) [0315901B, FKZ 01EO1002]
- Deutsche Forschungsgemeinschaft [DFG Hu 528/14, DFG Hu 528/15, DFG Hu 528/16, DFG Hu 528/17]
- European Union
- 'Jena School for Microbial Communication' (JSMC)
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Candida albicans and C.glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C.albicans and C.glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C.albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C.glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.
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