Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 122, Issue 1-2, Pages 9-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(01)00444-1
Keywords
phosphatidylinositol 3 '-kinase; Akt; Stat3; IL-10; IGF-I; apoptosis
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Funding
- NIA NIH HHS [AG-16710] Funding Source: Medline
- NIMH NIH HHS [MH-51569] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH051569] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016710] Funding Source: NIH RePORTER
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IL-10 is an anti-inflammatory cytokine that has recently been shown to promote survival of neurons and glia. Here we establish that IL-10 induces phosphorylation of Stat3 on Tyr(705) and serves as a survival factor for N13 microglial cells. Recombinant IL-10 (10 ng/ml) decreases growth factor withdrawal-induced apoptosis by 50%, as assessed by TUNEL. In contrast to IL-10, IGF-I increases enzymatic activity of PI 3-kinase and causes phosphorylation on serine(473) of Akt but does not prevent microglial apoptosis. These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway. (C) 2002 Elsevier Science B.V. All rights reserved.
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