Journal
CELLULAR MICROBIOLOGY
Volume 15, Issue 8, Pages 1285-1303Publisher
WILEY
DOI: 10.1111/cmi.12123
Keywords
-
Categories
Funding
- CNRS
- Ministere de l'Education Nationale de la Recherche et de la Technologie
- Conseil Regional d'Aquitaine
- LabEx ParaFrap (French Parasitology Alliance for Health Care)
- Global Alliance for Livestock Veterinary Medicine (GALVmed)
- UK Government's Department for International Development (DFID), GALVmed's Animal African Trypanosomosis Programme (DFID Programme: Controlling African Animal TRYPANOSOMOSIS (AAT) [202040-101]
- CEVA sante animale (Libourne, France)
Ask authors/readers for more resources
Trypanosomal infection-induced anaemia is a devastating scourge for cattle in widespread regions. Although Trypanosoma vivax is considered as one of the most important parasites regarding economic impact in Africa and South America, very few in-depth studies have been conducted due to the difficulty of manipulating this parasite. Several hypotheses were proposed to explain trypanosome induced-anaemia but mechanisms have not yet been elucidated. Here, we characterized a multigenic family of trans-sialidases in T.vivax, some of which are released into the host serum during infection. These enzymes are able to trigger erythrophagocytosis by desialylating the major surface erythrocytes sialoglycoproteins, the glycophorins. Using an ex vivo assay to quantify erythrophagocytosis throughout infection, we showed that erythrocyte desialylation alone results in significant levels of anaemia during the acute phase of the disease. Characterization of virulence factors such as the trans-sialidases is vital to develop a control strategy against the disease or parasite.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available