Journal
CELLULAR MICROBIOLOGY
Volume 15, Issue 7, Pages 1079-1087Publisher
WILEY
DOI: 10.1111/cmi.12140
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Funding
- NIAID NIH HHS [T32 AI007638] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007753] Funding Source: Medline
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Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity. Here we discuss both host mechanisms of amino acid starvation and the diverse adaptations of pathogens to their nutrient-deprived environments. These processes provide both key insights into immune subversion and new targets for drug development.
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