Journal
CELLULAR MICROBIOLOGY
Volume 14, Issue 3, Pages 343-+Publisher
WILEY
DOI: 10.1111/j.1462-5822.2011.01741.x
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Funding
- Brazilian Council for Scientific and Technological Development (CNPq)
- Medical Research Council, UK [U117584248]
- European Community [242095]
- Private Foundation CELLEX (Catalonia, Spain)
- Spanish Ministery of Science and Innovation [SAF2009-07760]
- MRC [MC_U117584248] Funding Source: UKRI
- Medical Research Council [MC_U117584248] Funding Source: researchfish
- ICREA Funding Source: Custom
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The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection. Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models.
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