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The role of the spleen in malaria

Journal

CELLULAR MICROBIOLOGY
Volume 14, Issue 3, Pages 343-+

Publisher

WILEY
DOI: 10.1111/j.1462-5822.2011.01741.x

Keywords

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Funding

  1. Brazilian Council for Scientific and Technological Development (CNPq)
  2. Medical Research Council, UK [U117584248]
  3. European Community [242095]
  4. Private Foundation CELLEX (Catalonia, Spain)
  5. Spanish Ministery of Science and Innovation [SAF2009-07760]
  6. MRC [MC_U117584248] Funding Source: UKRI
  7. Medical Research Council [MC_U117584248] Funding Source: researchfish
  8. ICREA Funding Source: Custom

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The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection. Here, the role of the spleen in malaria is reviewed with special emphasis in lessons learned from human infections and mouse models.

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