Journal
CELLULAR MICROBIOLOGY
Volume 15, Issue 3, Pages 403-411Publisher
WILEY
DOI: 10.1111/cmi.12067
Keywords
-
Categories
Funding
- MRC Career Development Award fellowship [MR/J009156/1]
- Lister Institute of Preventative Medicine Prize fellowship
- Wellcome Trust [088148/Z/09/Z]
- MRC [MR/J008176/1]
- Medical Research Council [MR/J008176/1, MR/J009156/1] Funding Source: researchfish
- MRC [MR/J009156/1, MR/J008176/1] Funding Source: UKRI
- Wellcome Trust [088148/Z/09/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
Cryptococcus is a potentially fatal fungal pathogen and a leading cause of death in immunocompromised patients. As an opportunistic and facultative intracellular pathogen of humans, Cryptococcus exhibits a complex set of interactions with the host immune system in general, and macrophages in particular. Cryptococcus is resistant to phagocytosis but is also able to survive and proliferate within the mature phagolysosome. It can cause the lysis of host cells, can be transferred between macrophages or exit non-lytically via vomocytosis. Efficient phagocytosis is reliant on opsonization and Cryptococcus has a number of anti-phagocytic strategies including formation of titan cells and a thick polysaccharide capsule. Following uptake, phagosome maturation appears to occur normally, but the internalized pathogen is able to survive and replicate. Here we review the interactions and host manipulation processes that occur within cryptococcal-infected macrophages and highlight areas for future research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available