Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 85, Issue 4, Pages 714-720Publisher
WILEY-LISS
DOI: 10.1002/jcb.10186
Keywords
EphA2; Myc; estrogen; metastasis; estrogen receptor; anti-estrogens; breast cancer
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Estrogen receptor and c-Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer.
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