Journal
NATURE IMMUNOLOGY
Volume 3, Issue 3, Pages 244-250Publisher
NATURE AMERICA INC
DOI: 10.1038/ni766
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The mechanisms by which immunological memory is maintained after infection or vaccination are still a matter of debate. Long-term survival of memory T cells does not require major histocompatibility complex (MHC) contact. We show here that compared with memory CD4(+) T cells that maintain contact with MHC class II, memory CD4(+) T cells deprived of MHC class II contact show distinct functional defects upon antigen re-encounter. Thus, in contrast to their survival, maintenance of the typical quality of memory T cells crucially depends on MHC-derived signals.
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