Journal
NEUROCHEMICAL RESEARCH
Volume 27, Issue 3, Pages 195-199Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1014876303062
Keywords
acrosome reaction; GABA(A); receptor agonist and antagonist; chlortetracycline assay; progesterone
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GABA triggers mammalian sperm acrosome reaction (AR). Here, evidence is presented, showing that rat spermatozoa contain GABA(A) receptors, composed of alpha(5), beta(1), and beta(3) subunits. The effects of GABA(A) receptor agonist and antagonist on the induction of AR in rat spermatozoa were assessed using the chlortetracycline assay. Muscimol, a GABA(A) receptor agonist, triggered AR; whereas bicuculline, a GABA(A) receptor antagonist and picrotoxin, a GABA(A) receptor/Cl- channel blocker, inhibited the ability of GAGA or progesterone to induce AR. In conclusion, GABA(A) receptors appear to mediate the action of progesterone in inducing AR in rat spermatozoa.
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