Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 57, Issue 3, Pages B115-B125Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/57.3.B115
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Funding
- NIA NIH HHS [AG05134, AG04390, AG08812] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P60AG008812, P01AG004390, P30AG008812] Funding Source: NIH RePORTER
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Under basal resting conditions most healthy physiologic systems demonstrate highly irregular, complex dynamics that represent interacting regulatory processes operating over multiple time scales. These processes prime the organism for an adaptive response. making it ready and able to react to sudden physiologic stresses. When the organism is perturbed or deviates from a given set of boundary conditions. most physiologic systems evoke closed-loop responses that operate over relatively short periods of time to restore the organism to equilibrium. This transiently alters the dynamics to a less complex, dominant response mode. which is denoted reactive tuning. Aging and disease are associated with a loss of complexity in resting dynamics and maladaptive responses to perturbations. These alterations in the dynamics of physiologic systems lead to functional decline and frailty. Nonlinear mathematical techniques that quantify physiologic dynamics may predict the onset of frailty, and interventions aimed toward restoring healthy dynamics may prevent functional decline.
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