Journal
CELLULAR MICROBIOLOGY
Volume 12, Issue 8, Pages 1026-1035Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1462-5822.2010.01491.x
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Funding
- Korea Science & Engineering Foundation through the Infection Signaling Network Research Center at Chungnam National University [R13-2007-020-01000-0]
- National Research Foundation of Korea [2007-0055006, 전06A1115] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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P>Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial strategy. With respect to host defences against mycobacteria, autophagy plays a crucial role in antimycobacterial resistance, and contributes to immune surveillance of intracellular pathogens and vaccine efficacy. Vitamin D3 contributes to host immune responses against Mycobacterium tuberculosis through LL-37/hCAP-18, which is the only cathelicidin identified to date in humans. In this review, we discuss recent advances in our understanding of host immune strategies against mycobacteria, including vitamin D-mediated innate immunity and autophagy activation. This review also addresses our current understanding regarding the autophagy connection to principal innate machinery, such as ubiquitin- or inflammasome-involved pathways. Integrated dialog between autophagy and innate immunity may contribute to adequate host immune defences against mycobacterial infection.
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