Journal
CELLULAR MICROBIOLOGY
Volume 11, Issue 3, Pages 461-474Publisher
WILEY
DOI: 10.1111/j.1462-5822.2008.01267.x
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Funding
- [R01 AI071147]
- [5 T32 AI07061-30]
- [1 T32 HD055148-10A1]
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We previously demonstrated that Vibrio cholerae is able to colonize the intestine of the fly to produce a lethal infection. Here we present the results of a genetic screen undertaken to identify factors that alter susceptibility of the fly to intestinal V. cholerae infection. In this model of infection, the Eiger/Wengen signalling pathway protects the fly against infection. Furthermore, mutations within the IMD signalling pathway increase resistance to intestinal V. cholerae infection and increase programmed cell death within the intestinal epithelium during infection. We propose that programmed cell death protects the intestinal epithelium against V. cholerae infection and therefore that the fly may serve as a useful model in which to study modulation of intestinal epithelial cell survival by commensal and pathogenic intestinal bacteria as well as the pathological processes leading to erosion of the intestinal epithelium and intestinal malignancy.
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