Journal
CELLULAR MICROBIOLOGY
Volume 10, Issue 4, Pages 899-907Publisher
WILEY
DOI: 10.1111/j.1462-5822.2007.01092.x
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Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- Intramural NIH HHS [Z01 AR041155-01] Funding Source: Medline
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Many strains of Vibrio cholerae produce a cytolysin (VCC) that forms oligomeric transmembrane pores responsible for vacuolization of several cell types in culture. Here we suggest that VCC could contribute to the T helper 2 (Th2) response seen in the natural infection; acting through TLR2, VCC enhances mast cells secretion of IL-4, IL-6 and TNF-alpha by 330-, 290- and 550-fold respectively. Moreover, VCC-induced cytokine production is dependent on increased cytosolic Ca2+ and on the presence of the Src family kinases Lyn and Fyn, known to be required for Fc epsilon RI-dependent activation of mast cells. These findings strongly suggest that VCC has a pro-inflammatory activity promoting a Th2-type immune profile.
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