Medicinal chemistry of N-acylhydrazones: Novel lead-compounds of analgesic, antinflammatory and antithrombotic drugs.

In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization or aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e,g. CBS-1108 and BW-755c. The analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. During this study was discovered dozen of active NAH compound, clarifying the structure-activity relationship for this series of NAH derivatives, indicating the pharmacophore character of the N-acylhydrazone functionality.