An improved procedure for the deamination of symmetrical 3,5-disubstituted 4-amino-1,2,4-triazoles

A number of symmetrical 3,5-disubstituted-4H-1,2,4-triazoles have been synthesized in good yields by deamination of the corresponding 4-amino-1,2,4-triazoles via reductive diazotation of these amino compounds in the presence of hypophosphorous acid. Analytical, spectral data and theoretical calculations confirmed the structures of the new triazole derivatives.