Journal
CELLULAR IMMUNOLOGY
Volume 279, Issue 1, Pages 12-20Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.08.005
Keywords
CLP; Myeloid-derived suppressor cells; Sepsis; Immune suppression
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Funding
- National Natural Science Foundation of China [30972576, 81101247]
- Scientific Research Fund of the scientific and technological department Hunan province [2010SK3038]
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Myeloid-derived suppressor cells (MDSCs) play a major role in modulating immune response, but only a few reports focused on MDSCs in the liver of sepsis states. Here, we investigated the changes in MDSCs in liver of the cecal ligation and puncture (CLP) mice. The results of flow cytometry showed that MDSCs accumulate in the liver site of mice after CLP for 7 days (CLP7d model mice) and settled to the livers of both normal and LPS stimulated mice. In vitro experiment showed a strong suppressive effect of MDSCs on the proliferation of CD4+ T lymphocytes of spleen. Furthermore, adoptive transfer of the liver MDSCs from CLP7d miceincreased the survival rate of acute hepatic failure (AHF) model mice in vivo. In conclusion, our data suggest that sepsis-induced liver MDSCs may have exert a key role in maintaining the immune homoeostasis in liver during the sepsis state. (c) 2012 Elsevier Inc. All rights reserved.
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