Journal
CELLULAR IMMUNOLOGY
Volume 270, Issue 2, Pages 198-206Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2011.05.008
Keywords
Food allergy; Mice; Weight loss; Ovalbumin; Adipose tissue; Lipolysis
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq/Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG/Brazil)
- CNPq
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To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrease in epididymal adipose tissue mass. This decrease was associated with increased lipolysis and local inflammation. In adipose tissue of allergic mice there were increased leukocyte rolling and adhesion in the microvasculature, increased number of leukocytes in the tissue, especially macrophages (F4/80(+) cells) and increased pro-inflammatory cytokines levels, including TNF-alpha. IL-6 and CCL2. In addition, we observed low serum concentrations of triglyceride, glucose, total cholesterol and free fatty acids in the allergic mice. Our results suggest that the induction of food allergy in mice leads to adipose tissue inflammation and systemic metabolic alterations that contribute to the weight loss observed. (C) 2011 Elsevier Inc. All rights reserved.
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