Journal
CELLULAR IMMUNOLOGY
Volume 267, Issue 2, Pages 102-108Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.12.003
Keywords
Cytokines; Monocytes; T cells
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Funding
- National Key Basic Research Program of China (973) [2007CB512404]
- National Natural Science Foundation of China [81072403]
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Interleukin 21 exerts a variety of regulatory effects on both innate and adaptive immune cells. Although the suppressive effect of IL-21 via the induction of IL-10 in mouse model has been defined, the inhibitory effect of IL-21 in humans is not well understood. In the present study, we showed that IL-21 induced IL-10 production by human naive CD4(+) T cells. Most of the IL-10-producing CD4(+) T cells did not co-express IFN-gamma. IL-21 increased the expression of IL-21R on activated naive CD4(+) T cells. Further analysis indicated that IL-21 induced phosphorylation of STAT1, STAT3 and STAT5 in activated naive CD4(+) T cells. In addition, IL-21 maintained the expression of CD16 on monocytes via the production of IL-10 by human naive CD4(+) T cells. Taken together, our data indicated that IL-21 had a modulating effect on monocytes at least in part by inducing IL-10 production. (C) 2011 Elsevier Inc. All rights reserved.
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