Journal
CELLULAR IMMUNOLOGY
Volume 262, Issue 2, Pages 89-95Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.02.008
Keywords
CD4 T cells; Cytotoxicity; IL-2; Perforin; Granzyme B; Viral infection
Categories
Funding
- PHS [AI-46530, AI-0672]
- Trudeau Institute
- NCRR COBRE [P20 RR15635]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR015635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [Z01AI000672, P01AI046530, R56AI067294] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R37AG025805] Funding Source: NIH RePORTER
Ask authors/readers for more resources
CD4 T cells have traditionally been regarded as helpers and regulators of adaptive immune responses; however, a novel role for CD4 T cells as direct mediators of protection against viral infections has emerged. CD4 T cells with cytolytic potential have been described for almost 40 years, but their role in host protection against infectious disease is only beginning to be realized. In this review, we describe the current literature identifying these cells in patients with various infections, mouse models of viral infection and our own work investigating the development of cytolytic CD4 cells in vivo and in vitro. CD4 CTL are no longer considered an artefact of cell culture and may play a physiological role in viral infections such as EBV, CMV, HIV and influenza. Therefore, vaccine strategies aimed at targeting CD4 CTL should be developed in conjunction with vaccines incorporating B cell and CD8 CTL epitopes. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available