Journal
CELLULAR IMMUNOLOGY
Volume 265, Issue 2, Pages 91-96Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.07.007
Keywords
Dendritic cells; Cyclic AMP; Treg cells; IL-10
Categories
Funding
- DFG [TR52 TPA1, SFB 548 A6, SFB 490 E6, KFO 183]
- Carl Zeiss Foundation
- Mainzer Forschungsforderungsprogramm des Fachbereichs Medizin (MAI-FOR)
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In humans and mice naturally occurring regulatory T cells (nTregs) are crucial for the maintenance of peripheral tolerance by controlling not only potentially autoreactive T cells but virtually all cells of the adaptive and innate immune system. Here we show that co-culture of murine dendritic cells (DC) and nTregs results in an immediate increase of cAMP in DC, responsible for a rapid down-regulation of costimulatory molecules (CD80, CD86). In addition, the inhibitory surface molecule B7-H3 on DC is up-regulated. Subsequently, nTreg-derived IL-10 inhibits the cytokine production (IL-6, IL-12) of suppressed DC therewith preserving their silent phenotype. Hence, our data indicate that nTregs effectively control exuberant immune responses by directly limiting the stimulatory capacity of DC via a sophisticated chronologic action of inhibitory signals. (C) 2010 Elsevier Inc. All rights reserved.
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