Journal
CELLULAR IMMUNOLOGY
Volume 263, Issue 2, Pages 138-147Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.03.019
Keywords
Cancer immunotherapy; Therapeutic vaccine; Immunological tolerance
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Induction of tumor-specific immunity is an attractive approach to cancer therapy, however to date every major pivotal trial has resulted in failure While the phenomena of tumor-mediated immune suppression has been known for decades, only recently have specific molecular pathways been elucidated, and for the first time, rationale means of intervening and observing results of intervention have been developed In this review we describe major advances in our understanding of tumor escape from immunological pressure and provide some possible therapeutic scenarios for enhancement of efficacy in future cancer vaccine trials (C) 2010 Elsevier Inc All rights reserved.
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