Journal
CELLULAR IMMUNOLOGY
Volume 262, Issue 1, Pages 1-5Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2010.01.003
Keywords
Dendritic cell; Human; Monocyte; Vaccine; LEAPS
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Funding
- NIH/NCRR Cleveland CTSA UL [1RR024989, R01 CA100163]
- NATIONAL CANCER INSTITUTE [R01CA100163] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024989] Funding Source: NIH RePORTER
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LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from go of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines. (C) 2010 Elsevier Inc. All rights reserved.
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