Journal
CELLULAR IMMUNOLOGY
Volume 259, Issue 1, Pages 1-4Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2009.06.002
Keywords
CpG; Mycobacterium tuberculosis; Phospholipase D; Phagolysosome
Categories
Funding
- Italian Ministry of University
Ask authors/readers for more resources
CpG oligodeoxynucleotides have been previously shown to enhance anti mycobacterial response in human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial immune response. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available