Spectrophotometric determination of some antidepressant drugs

Amitriptyline and desipramine hydrochlorides react with niobium (V) thiocyanate complex forming yellow ion-association compounds. These compounds are insoluble in water, but fairly soluble in organic solvents. The formation and extraction conditions of the compounds have been established, and a new spectrophotometric method has been developed for the determination of amitriptyline and desipramine in the concentration range of 1-12 mug/mL and 1-6 mug/mL, respectively.