Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 33, Issue 8, Pages 1143-1148Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-013-9980-1
Keywords
MicroRNA; Glioma; Connexin43; mRNA
Categories
Ask authors/readers for more resources
MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected glioma cells also demonstrated increased growth after in vivo transplantation. We further identified that miR-125b inhibits Connexin43 expression, and the overexpression of Connexin43 antagonizes the effects of miR-125b in cell growth and anti-apoptosis. We conclude that miR-125b regulates glioma growth partly through Connexin43 protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available