Journal
BRAIN RESEARCH BULLETIN
Volume 57, Issue 1, Pages 85-91Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0361-9230(01)00639-6
Keywords
bcl-2 gene; transgenic mice; developmental cell death; supernumerary neurons; behavior
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In humans, perturbations in the developmental neuronal death leading to an excess of neurons could be associated with developmental neuropsychiatric disorders. Hu-bcl-2 transgenic mice appear to be a valuable tool to study the functional role of developmental programmed cell death. Indeed, the over-expression of the anti-apoptotic gene bcl-2 decreases developmental neuronal death and Hu-bcl-2 mice present supernumerary neurons in several brain regions. A detailed behavioral analysis of these mice revealed selective deficits. Hu-bcl-2 mice have normal vision, general activity and motor skills. Only the most complex behavior like anxiety and learning abilities are impaired in these mice. (C) 2002 Elsevier Science Inc.
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