Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 1, Issue 1, Pages 37-44Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd705
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It is almost axiomatic that patients vary widely in their beneficial responses to drug therapy, and serious and apparently unpredictable adverse drug reactions continue to be a major public health problem. Here, we discuss the concept that genetic variants might determine much of this variability in drug response, and propose an algorithm to enable further evaluation of the benefits and pitfalls of this enticing possibility.
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