Journal
NATURE REVIEWS GENETICS
Volume 3, Issue 1, Pages 65-72Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg705
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Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (similar to5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.
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