Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 31, Issue 6, Pages 939-948Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-011-9691-4
Keywords
Alzheimer's disease; Synapse degeneration; A beta oligomers; mGluR5; Fragile X syndrome; Insulin dysfunction
Categories
Funding
- NIA NIH HHS [R01 AG029460, R01 AG029460-03] Funding Source: Medline
Ask authors/readers for more resources
A beta oligomers cause a collection of molecular events associated with memory loss in Alzheimer's disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of A beta oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity-especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available