Journal
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
Volume 11, Issue 3, Pages 206-209Publisher
H E C PRESS, HEALTHY EATING CLUB PTY LTD
DOI: 10.1046/j.1440-6047.2002.00292.x
Keywords
aqueous extract; enzymic antioxidants; Phaseolus vulgaris; streptozotocin-induced diabetes
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The antioxidant effect of an aqueous extract of Phaseolus vulgaris pods, an indigenous plant used in Ayurvedic medicine in India, was studied in rats with streptozotocin-induced diabetes. Oral administration of Phaseolus vulgaris pod extract (PPEt; 200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the liver and kidneys of rats with streptozotocin-induced diabetes. These results clearly show the antioxidant property of PPEt. The effect of PPEt at 200 mg/kg body weight was more effective than glibenclamide.
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