Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 39, Issue 1, Pages 61-72Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00005344-200201000-00008
Keywords
calcium sensitization; dobutamine; energetics; EMD 57033; mechanical efficiency; regional myocardial stunning
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External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVo(2)) are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (E-es), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty minutes after regional stunning in 11 open chest pigs by two 10-min coronary occlusions separated by 10 min of reperfusion, dobutamine (0.5, 1, and 2 mug x kg(-1) x min(-1)) was infused, after an ample washout period followed by infusion of EMD 57033 (0.05, 0.1, 0.2 mg x kg(-1) x min(-1)). Stunning decreased E-es (30%), EWwp (56%), EWmax (63%), EETwp (34%), EETmax (33%) and mechanical efficiency (55%), but MVo(2) was unaffected. EWwp, EWmax, EETwp, and EETmax increased similarly with the two drugs, whereas MVo(2) increased only after dobutamine. Consequently, mechanical efficiency increased linearly with contractility during EMD 57033 infusion but remained constant during infusion of dobutamine.
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