Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 26, Issue 1, Pages 53-57Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0278-5846(01)00218-4
Keywords
bromperidol; clinical response; plasma drug concentrations; prolactin response
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Therapeutic profiles of bromperidol and their relationship with plasma drug concentration and prolactin response were investigated in 30 acutely exacerbated schizophrenic patients treated with randomly allocated fixed-doses of bromperidol (6, 12 or 18 mg/day) for 3 weeks. The mean values (+/-S.D.) of percentage improvement at 3 weeks in total Brief Psychiatric Rating Scale (BPRS) and five subgrouped symptoms were 59.8 +/- 29.2% for total, 64.6 +/- 37.5% for positive, 73.3 +/- 33.7% for excitement, 80.2 +/- 45.5% for cognitive, 43.1 +/- 46.5% for negative and 49.6 +/- 46.8% for anxiety-depression symptoms, respectively. Twenty (67%) of 30 patients were responders defined as having 50% or more symptom reduction significantly greater in responders than those in nonresponders after 2 weeks. Mean plasma bromperidol concentration in patients with 50% or more reduction in positive symptoms was significantly higher than in the others (8.2 +/- 4.7 vs. 4.1 +/- 1.8 ng/ml, P < .05). Percentage improvement in total BPRS at I and 2 weeks were correlated well with that at 3 weeks. These findings suggest that an early improvement in positive and anxiety-depression symptoms results in favorable outcome of total response to bromperidol treatment. Plasma drug monitoring may have a limited predictive value for improvement in positive symptoms. (C) 2001 Elsevier Science Inc. All rights reserved.
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