Neurotoxicologic sequelae of tributyltin intoxication in rats

Tributyltin oxide (TBTO) is a commonly used biocide. The purpose of this study is to correlate the toxicity of TBTO with the alterations of brain neurotransmitters and ATPases. TBTO was given by stomach tube to rats at either 37.5 or 75 mg kg(-1) for 3 consecutive days. Nervous signs appeared in treated animals and the mortality reached 12 and 30%. respectively. The levels of brain dopamine, norepinephrine and serotonin decreased in a dose-dependent manner. The activities of brain total ATPase, Mg2+-ATPase and Na+/K+-ATPase were suppressed. The activity of Na+/K+-ATPase was more severely affected than that of Mg2+-ATPase. Histopathological changes in brain included hyperaemia, focal haemorrhages in vacuolated myelinated fibres, chromatolysis, or complete necrosis of neurons, degenerative changes, or complete absence of purkinje cells in the cerebellum. (C) 2002 Elsevier Science Ltd.