Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 3, Pages 537-556Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1760-7
Keywords
Cytoskeleton; Actin; T cells; Immunological synapse; T cell receptor; Cytotoxicity; Signal transduction
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIAID NIH HHS [R01 AI087644] Funding Source: Medline
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Transient,specialized cell-cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function.
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