Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 2, Pages 327-337Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1748-3
Keywords
Heterochromatin; Signal transduction; Cell proliferation; Cell differentiation; Epigenetic regulation; Genome stability
Categories
Funding
- National Natural Science Foundation of China (NSFC) [31271573, 31228015, 31201007, 81470846]
- 973 Program [2012CB825504]
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More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development.
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