Journal
IMMUNITY
Volume 16, Issue 3, Pages 365-377Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(02)00289-3
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI035296, R37AI027998, R01AI039614, R01AI027998] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI 35296, AI 39614, AI 27998] Funding Source: Medline
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A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.
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