Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 7, Pages 1303-1316Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-014-1796-8
Keywords
Macrophages; Phenotype; Polarization; Microenvironment; Mechanotransduction
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Funding
- NICHD NIH HHS [T32 HD060555] Funding Source: Medline
- NIDCR NIH HHS [DP2 DE023319] Funding Source: Medline
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Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atherosclerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues. As alterations in the physical microenvironment often underlie pathophysiological states, an understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis.
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