Journal
MICROBES AND INFECTION
Volume 4, Issue 3, Pages 325-331Publisher
ELSEVIER
DOI: 10.1016/S1286-4579(02)01545-9
Keywords
outer membrane proteins; pathogenesis; adaptation; resistance
Categories
Funding
- NIAID NIH HHS [R21 AI115358] Funding Source: Medline
- NIEHS NIH HHS [P30 ES006096] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI115358] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES006096] Funding Source: NIH RePORTER
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Outer membrane proteins (OMPs) of Gram-negative bacteria have diverse functions and are directly involved in the interaction with various environments encountered by pathogenic organisms. Thus, OMPs represent important virulence factors and play essential roles in bacterial adaptation to host niches, which are usually hostile to invading pathogens. Understanding the structure and functions of bacterial OMPs will facilitate the design of antimicrobial drugs and vaccines. In this paper, we will present a brief review on OMPs that contribute to bacterial adaptive responses including iron uptake, antimicrobial peptide resistance, serum resistance, and drug/bile resistance. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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