Related references
Note: Only part of the references are listed.Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Megan J. Bywater et al.
CANCER CELL (2012)
The nucleolar detention pathway A cellular strategy for regulating molecular networks
Timothy E. Audas et al.
CELL CYCLE (2012)
Interactions of Nucleolin and Ribosomal Protein L26 (RPL26) in Translational Control of Human p53 mRNA
Jing Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
Erik S. Welf et al.
JOURNAL OF CELL BIOLOGY (2012)
Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA
Timothy E. Audas et al.
MOLECULAR CELL (2012)
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Denis Drygin et al.
CANCER RESEARCH (2011)
Tissue-Specific Therapeutic Targeting of p53 in Cancer: One Size Does Not Fit All
Nikolina Vlatkovic et al.
CURRENT PHARMACEUTICAL DESIGN (2011)
CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport
Berengere Pradet-Balade et al.
EMBO JOURNAL (2011)
The nucleolus directly regulates p53 export and degradation
Mark T. Boyd et al.
JOURNAL OF CELL BIOLOGY (2011)
Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling
Claus Rieker et al.
JOURNAL OF NEUROSCIENCE (2011)
Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation
Henna M. Moore et al.
MOLECULAR & CELLULAR PROTEOMICS (2011)
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Shankar Balasubramanian et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability
L. Latonen et al.
ONCOGENE (2011)
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes
Clifford P. Brangwynne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer
Denis Drygin et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction
Everardo Macias et al.
CANCER CELL (2010)
Mdm2-mediated ubiquitylation: p53 and beyond
J-C Marine et al.
CELL DEATH AND DIFFERENTIATION (2010)
Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis
Yumi Uetake et al.
CURRENT BIOLOGY (2010)
Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels
Kaspar Burger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Defects in 18 S or 28 S rRNA Processing Activate the p53 Pathway
Michael Holzel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
p53 localizes to intranucleolar regions distinct from the ribosome production compartments
Tim Krueger et al.
JOURNAL OF CELL SCIENCE (2010)
The Nucleolus under Stress
Severine Boulon et al.
MOLECULAR CELL (2010)
A Protein Inventory of Human Ribosome Biogenesis Reveals an Essential Function of Exportin 5 in 60S Subunit Export
Thomas Wild et al.
PLOS BIOLOGY (2010)
Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly
Hsiao-Chun Huang et al.
CANCER CELL (2009)
Signaling to p53: Ribosomal Proteins Find Their Way
Yanping Zhang et al.
CANCER CELL (2009)
Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Denis Drygin et al.
CANCER RESEARCH (2009)
Specific activation of the p53 pathway by low dose actinomycin D A new route to p53 based cyclotherapy
Meng Ling Choong et al.
CELL CYCLE (2009)
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
Koji Okamoto et al.
FEBS LETTERS (2009)
In search of nonribosomal nucleolar protein function and regulation
Thoru Pederson et al.
JOURNAL OF CELL BIOLOGY (2009)
How Common Are Extraribosomal Functions of Ribosomal Proteins?
Jonathan R. Warner et al.
MOLECULAR CELL (2009)
Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2
Yan Zhu et al.
MOLECULAR CELL (2009)
Absence of nucleolar disruption after impairment of 40s ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction
Stefano Fumagalli et al.
NATURE CELL BIOLOGY (2009)
NOPdb: Nucleolar Proteome Database-2008 update
Yasmeen Ahmad et al.
NUCLEIC ACIDS RESEARCH (2009)
Tumor Suppressive Functions of p53
Jack T. Zilfou et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown et al.
NATURE REVIEWS CANCER (2009)
Novel substrates and functions for the ubiquitin-like molecule NEDD8
Dimitris P. Xirodimas
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
In nucleoli, the steady state of nucleolar proteins is leptomycin B-sensitive
Eleonora Muro et al.
BIOLOGY OF THE CELL (2008)
p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53
Stephanie Carter et al.
CELL CYCLE (2008)
Inhibition of nucleolar transcription as a trigger for neuronal apoptosis
K. Kalita et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Yaara Ofir-Rosenfeld et al.
MOLECULAR CELL (2008)
The genetics of the p53 pathway, apoptosis and cancer therapy
Alexei Vazquez et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Nucleolus: the fascinating nuclear body
Valentina Sirri et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2008)
Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry
Andrea Scharf et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2007)
Selective induction of apoptosis by leptomycin B in keratinocytes expressing HPV oncogenes
Lindsey J. Gray et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
A regulatory role for CRM1 in the multi-directional trafficking of splicing snRNPs in the mammalian nucleus
Judith Sleeman
JOURNAL OF CELL SCIENCE (2007)
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit
Michaela Rohrmoser et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins
Yun Wah Lam et al.
CURRENT BIOLOGY (2007)
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
Stephanie Carter et al.
NATURE CELL BIOLOGY (2007)
5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction
Xiao-Xin Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Monoubiquitylation promotes mitochondrial p53 translocation
Natasha D. Marchenko et al.
EMBO JOURNAL (2007)
Molecular mechanisms of resistance and toxicity associated with platinating agents
Cara A. Rabik et al.
CANCER TREATMENT REVIEWS (2007)
RNA viruses: hijacking the dynamic nucleolus
Julian A. Hiscox
NATURE REVIEWS MICROBIOLOGY (2007)
MDM2 inhibitors for cancer therapy
Lyubomir T. Vassilev
TRENDS IN MOLECULAR MEDICINE (2007)
MDMX regulation of p53 response to ribosomal stress
Daniele M. Gilkes et al.
EMBO JOURNAL (2006)
Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism
Mu-Shui Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
Compartmentation of the nucleolar processing proteins in the granular component is a CK2-driven process
Emilie Louvet et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex
Thomas Grimm et al.
NUCLEIC ACIDS RESEARCH (2006)
Nucleolus: from structure to dynamics
D Hernandez-Verdun
HISTOCHEMISTRY AND CELL BIOLOGY (2006)
Proteasomes degrade proteins in focal subdomains of the human cell nucleus
TD Rockel et al.
JOURNAL OF CELL SCIENCE (2005)
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
M Takagi et al.
CELL (2005)
Regulation of ubiquitin ligase dynamics by the nucleolus
K Mekhail et al.
JOURNAL OF CELL BIOLOGY (2005)
Measuring fast dynamics in solutions and cells with a laser scanning microscope
MA Digman et al.
BIOPHYSICAL JOURNAL (2005)
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis
XJ Yuan et al.
MOLECULAR CELL (2005)
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
SS Grewal et al.
NATURE CELL BIOLOGY (2005)
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
C Grandori et al.
NATURE CELL BIOLOGY (2005)
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
A Arabi et al.
NATURE CELL BIOLOGY (2005)
A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin
RYL Tsai et al.
JOURNAL OF CELL BIOLOGY (2005)
RNA polymerases I and III, growth control and cancer
RJ White
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
A dynamic role of HAUSP in the p53-Mdm2 pathway
MY Li et al.
MOLECULAR CELL (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23
D Bertwistle et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells
AKL Leung et al.
JOURNAL OF CELL BIOLOGY (2004)
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
C Vogel et al.
ONCOGENE (2004)
Opinion - Transcription - guarding the genome by sensing DNA damage
M Ljungman et al.
NATURE REVIEWS CANCER (2004)
PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli
S Boulon et al.
MOLECULAR CELL (2004)
Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2
HM O'Hagan et al.
ONCOGENE (2004)
Targeting cell cycle and apoptosis for the treatment of human malignancies
AM Senderowicz
CURRENT OPINION IN CELL BIOLOGY (2004)
HIF activation by pH-dependent nucleolar sequestration of VHL
K Mekhail et al.
NATURE CELL BIOLOGY (2004)
The nucleolus and transcription of ribosomal genes
I Raska et al.
BIOLOGY OF THE CELL (2004)
Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2
MY Li et al.
SCIENCE (2003)
mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
KM Hannan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
CP Rubbi et al.
EMBO JOURNAL (2003)
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage
TW Joseph et al.
FASEB JOURNAL (2003)
MDM2 promotes ubiquitination and degradation of MDMX
Y Pan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulation of HDM2 activity by the ribosomal protein L11
MAE Lohrum et al.
CANCER CELL (2003)
5-Fluorouracil: Mechanisms of action and clinical strategies
DB Longley et al.
NATURE REVIEWS CANCER (2003)
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
J Zhao et al.
MOLECULAR CELL (2003)
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing
M Sugimoto et al.
MOLECULAR CELL (2003)
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
YP Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction
L Latonen et al.
CELLULAR SIGNALLING (2003)
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
MY Li et al.
NATURE (2002)
Cyclin-dependent kinases govern formation and maintenance of the nucleolus
V Sirri et al.
JOURNAL OF CELL BIOLOGY (2002)
Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
YH Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Directed proteomic analysis of the human nucleolus
JS Andersen et al.
CURRENT BIOLOGY (2002)
Directed proteomic analysis of the human nucleolus
JS Andersen et al.
CURRENT BIOLOGY (2002)
Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells
RM Huang et al.
FASEB JOURNAL (2002)
Therapeutic exploitation of the p53 pathway
DP Lane et al.
TRENDS IN MOLECULAR MEDICINE (2002)
Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
JJ Gu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Nucleolar damage correlates with neurotoxicity induced by different platinum drugs
MJ McKeage et al.
BRITISH JOURNAL OF CANCER (2001)
Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53
DP Xirodimas et al.
EXPERIMENTAL CELL RESEARCH (2001)
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
D Xirodimas et al.
ONCOGENE (2001)
Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle:: Effects of nucleolar protein bop1 on G1/S transition
DG Pestov et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos et al.
NATURE CELL BIOLOGY (2001)
Post-translational modifications and activation of p53 by genotoxic stresses
E Appella et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells
DY Chen et al.
JOURNAL OF CELL BIOLOGY (2001)
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
SD Boyd et al.
NATURE CELL BIOLOGY (2000)
The MDM2 RING-finger domain is required to promote p53 nuclear export
RK Geyer et al.
NATURE CELL BIOLOGY (2000)
Repression of RNA polymerase I transcription by the tumor suppressor p53
WG Zhai et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Molecular mechanisms involved in cisplatin cytotoxicity
P Jordan et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
M Ljungman
NEOPLASIA (2000)
Stress signals utilize multiple pathways to stabilize p53
M Ashcroft et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
The ARF/p53 pathway
CJ Sherr et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2000)
In vivo release of mitotic silencing of ribosomal gene transcription does not give rise to precursor ribosomal RNA processing
V Sirri et al.
JOURNAL OF CELL BIOLOGY (2000)
Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus
CP Rubbi et al.
ONCOGENE (2000)
Identification of a cryptic nucleolar-localization signal in MDM2
MAE Lohrum et al.
NATURE CELL BIOLOGY (2000)
Share Paper
