Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 71, Issue 3, Pages 379-404Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1343-z
Keywords
Histone variants; Histone chaperones; Histone post-translational modifications; Cancer; Chromatin remodeler
Categories
Funding
- NCI [T32-CA078207]
- Melanoma Research Development Award (Department of Dermatology, Mount Sinai)
- Ellison Medical Foundation New Scholar Award
- Association for International Cancer Research, Hirschl/Weill-Caulier Research Award
- NCI/NIH [R01CA154683]
Ask authors/readers for more resources
Histone variants are key players in shaping chromatin structure, and, thus, in regulating fundamental cellular processes such as chromosome segregation and gene expression. Emerging evidence points towards a role for histone variants in contributing to tumor progression, and, recently, the first cancer-associated mutation in a histone variant-encoding gene was reported. In addition, genetic alterations of the histone chaperones that specifically regulate chromatin incorporation of histone variants are rapidly being uncovered in numerous cancers. Collectively, these findings implicate histone variants as potential drivers of cancer initiation and/or progression, and, therefore, targeting histone deposition or the chromatin remodeling machinery may be of therapeutic value. Here, we review the mammalian histone variants of the H2A and H3 families in their respective cellular functions, and their involvement in tumor biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available